克罗米酚对成年低促性腺素性功能减退症有效

纽约市（法新社健康初版）1月末四日报道：据刊出在12月末出初版的《生育与不育》杂志的一项报告声称克罗米醇对其余部分低促性腺素性功能减退的年长病人利于。来自谢菲尔德阿拉巴马私立大学的该报告的第一笔记Scott J. Whitten博士在做路透通讯社采访坦言：“原发性或获得性HH病人在做侵害性更大和比较较贵的疗法（例如切除促性腺激素类）前顺利进行4个月末的克罗米醇试验性疗法是利于的。”Whitten博士和同事研究了克罗米醇对10名HH年长病人（HH是导致年长不育的少见因素）是否有效。报告援引克罗米醇疗法1年后，4名卡尔曼(田氏)综合征病人中只有一名病人的受精卵沸点减低而全垂体功能减退症病人的受精卵缺乏病人皆没有取得强化。也就是感叹，该报告声称3名成年胃癌的原发性HH年长病人经过3个月末克罗米醇的疗法受精卵沸点有了明显减低。迄今为止该组病人已有两名恢复了不孕。Whitten博士感叹：“除非对克罗米醇疗法没有反应，我们不会因为副作用停止对病人使用该抗生素。”最后笔记总结感叹：“因为必需极小，对HH病人促性腺激素类抗生素和克罗米醇的随机研究不足以顺利进行，然而并用多系列的严密选择标准对病人顺利进行分级可能帮助进一步验证克罗米醇恢复年长低不孕的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编者：红色幻想

编者： 张靖